Banking DNA sequences

Guidelines for DNA banking. Report of the Clinical Genetics Society working party on DNA banking.

DNA / RNA Sequences Protein Sequences

Many scientiic disciplines (e.g., biology, astrophysics, particle physics, earth sciences) are shifting from in vitro to in silico research as more physical processes and natural phenomena are simulated in a computer (in silico) instead of being observed (in vitro). In many of these virtual laboratories, the computations involved are very complex and long lived. Currently, users are required to...

DNA Sequences

L. Vigilant et al. (1) recently presented "the strongest support yet for the placement of [their] common mtDNA [mitochondrial DNA] ancestor in Africa some 200,000 years ago." This support stems from a tree estimated by maximum parsimony from mtDNA sequence data with the use of the computer program PAUP (2). The African origin is inferred from this tree because (i) the most basal splits are amon...

Comparison of DNA sequences with protein sequences.

The FASTA package of sequence comparison programs has been expanded to include FASTX and FASTY, which compare a DNA sequence to a protein sequence database, translating the DNA sequence in three frames and aligning the translated DNA sequence to each sequence in the protein database, allowing gaps and frameshifts. Also new are TFASTX and TFASTY, which compare a protein sequence to a DNA sequenc...

DNA Target Sequences